Endocrine Abstracts

Background: Low bone mineral density (BMD) and osteoporosis are the frequent consequences of Turner Syndrome (TS).Objective and hypotheses: We examined the BMD in TS girls with different age and karyotype.Methods: Measurements of BMD (g/cm2), Z-score (S.D.) were conducted in 26 girls using X-ray absorptiometry (DEXA) at the lumbar spine L2–L4 depending on the child’s age.<p class="ab...

Background: One of the markers of bone metabolism is osteocalcin (OC) and Its elevated level indicates osteoporosis.Objective and hypotheses: We investigated the OC level in 14 girls with TS (45,X (n=8), 45,X/46,XX (n=3), structural abnormalities of chromosome X (n=3): seven patients at 4–11 year and 7 – at 12–18 year.Method: DEXA (Z-score, S.D.), serum levels of OC,...

Introduction: There is some variation in the practice of gonadectomy for individuals with Differences of Sex Development (DSD) worldwide. This quality improvement project aims to undertake continued surveillance of the occurrence of gonadectomy in suspected or confirmed cases of DSD.Methods: Participating centres from the International-DSD Registry are sent a monthly email asking if a gonadectomy has been performed. A se...

Introduction: Cardiovascular disease is the commonest cause of death (absolute-excess-risk:41%) in Turner Syndrome (TS). Hypertension is a major risk for circulatory-disease (up to 60%) and a key modifiable-risk factor of aortopathy, ischemic heart disease and stroke in TS. There is no current consensus for hypertension diagnosis/management in TS.Methods: Retrospective multi-centre observational study of patients aged &#...

Background: Testicular Adrenal Rest Tumors (TART) in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21OHD) or 11-hydroxylase deficiency (11OHD) are benign lesions causing testicular damage and infertility. We hypothesize that high ACTH exposure due to poor hormonal control during early life is promoting development of TART later in life.Objective: This study aims to examine the relation between early CAH diagnosis and cons...

Background: In 2019, the International CAH Registry (I-CAH) performed a benchmarking exercise of acute adrenal insufficiency related adverse events including adrenal crises (AC) and sick day episodes (SDE).Methods: In 2022, I-CAH data on children aged <18 years at first visit with 21-hydroxylase deficiency CAH from 35 centres in 19 countries were analysed to examine the current occurrence of SDE and AC and compared t...